Toxoplasma MIC2 Is a Major Determinant of Invasion and Virulence
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Toxoplasma MIC2 Is a Major Determinant of Invasion and Virulence
Like its apicomplexan kin, the obligate intracellular protozoan Toxoplasma gondii actively invades mammalian cells and uses a unique form of gliding motility. The recent identification of several transmembrane adhesive complexes, potentially capable of gripping external receptors and the sub-membrane actinomyosin motor, suggests that the parasite has multiple options for host-cell recognition a...
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Host cell invasion by apicomplexan parasites is accompanied by the rapid, polarized secretion of parasite proteins that are involved in cell attachment. The Toxoplasma gondii micronemal protein MIC2 contains several extracellular adhesive domains, a transmembrane domain, and a short cytoplasmic tail. Following apical secretion, MIC2 is transiently present on the parasite surface before being tr...
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ژورنال
عنوان ژورنال: PLoS Pathogens
سال: 2006
ISSN: 1553-7374
DOI: 10.1371/journal.ppat.0020084